<br /> <p>LOW DOSE NALTREXONE</p><br /> <p><a href="http://www.medicine-consult.com/home" target="_self">HOME</a></p><br /> <p><a href="http://www.lowdosenaltrexone.org" target="_blank">www.lowdosenaltrexone.org</a></p><br /> <p>WHAT IS NALTREXONE?</p><br /> <p></p><p>Naltrexone is an opioid receptor antagonist used primarily in the management of alcohol dependence and opioid dependence. </p><p>It is marketed in generic form as its hydrochloride salt, naltrexone hydrochloride, and marketed under the trade names Revia </p><p>and Depade. In some countries including the United States, a once-monthly extended-release injectable formulation is marketed </p><p>under the trade name Vivitrol. Also in the US, Methylnaltrexone Bromide, a closely related drug, is marketed as Relistor, for the </p><p>treatment of opioid induced constipation.</p><p></p><br /> <p>Naltrexone should not be confused with naloxone (which is used in emergency cases of overdose rather than for longer-term dependence control) nor nalorphine. Both nalorphine and naloxone are full antagonists and will treat an opioid overdose, but naltrexone is longer-acting than naloxone (although neither is an irreversible antagonist like naloxazone), making naloxone a better emergency antidote.</p><br /> <p>WHY USE LOW DOSE NALTREXONE?</p><br /> <p>There has been exciting research on low dose naltrexone(LDN) since 1985. The basic premise is that certain people or certain conditions can</p><p>be helped with the use of very low daily doses of naltrexone. The first response the body has to any trauma, infection or inflammation is to </p><p>release its stores of naturally occurring beta-endorphins and metenkephalins. For a long while the medical world thought this was solely a </p><p>response to decrease pain. But we have since learned that these substances actually trigger the immune response. I have some additional postulates that I will share with you later. Research has proven that diseases that tax the immune system such as HIV/AIDS, Multiple Sclerosis, Auto-immune disease, cancer and the like can significantly be impacted by LDN or be entirely cured. </p><br /> <p>HOW DOES LDN WORK?</p><br /> <p>When a dose of naltrexone is given, the brain percieves that it has no endorphins. In response the brain tries to produce more. In reality it does have these chemicals but now the body will have a greater supply to draw from. This then can be used to increase or normalize the natural immune respone. LDN is typically given at a dose of 4.5mg per day, taken before sleep. It is when a body is sleeping that the endorphin supply is regenerated. The dosage varies according to the condition being treated and an individuals needs and condition.</p><br /> <p>ADDITIONAL LDN THOUGHTS</p><br /> <p>Could the reason LDN is working so well is that there is an underlying sleep disturbance stopping the production of endorphins? Or is there also a connection with adrenal fatigue thus a lack of cortisol? It to is produced only at night during sound sleep. Could an opiod addiction be caused by a lack of natural endorphin production? All questions that over time will be answered but relationships I constantly think about in connection with LDN.</p>
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